In fact, we are already too late to intervene in a way that could prevent humanitarian crisis. It is really my last and desperate call for action as Omicron is now causing a fast and large-scale immune escape in vaccines. So, this is simply accelerating.
Immune escape is accelerating.
It is really escalating and for me it is really unbelievable. I cannot understand how it is possible that all these researchers that are studying these mutations and this mutational escape of the virus are not ringing the alarm bell.
So I don't know, I really don't know. Is it stupidity or is it really willful blindness? The scientists who are analyzing all these new mutations that are simply accumulating, we have seen them accumulating even over the last days, over the last weeks. For the scientists, this doesn't seem to be a reason for panic really. I mean, they see this fulminant immune escape as in fact a great opportunity for making publications.
When humanity is on the brink of humanitarian crisis, we need to gather information that is able to predict with a high level of fidelity, with a high level of confidence what is going to happen.
And they are not able to do this simply because they don't see the forest for the trees. And why is this? And here comes the thing. It is simply because they don't understand the underlying immune interaction between the virus and the immune system. They all agree that the convergent evolution of what they call themselves worrisome variants and the resulting immune escape, that all this is due to immune selection pressure that is placed on the virus.
All this is very, very clear to them. But nobody dares to mention that this huge immune selection pressure has to do with the mass vaccination. I cannot believe this. And it's even worse:
On the contrary, these scientists who are excelling in what I call molecular stamp collection, these are the guys who are now also advocating for the development of broad-spectrum vaccines and antibody drugs. So continuation, please, with the vaccine program. And so, when I'm talking about the molecular stamp collection, I'm showing here a graph.
So by hiding the stronger neutralizing epitopes, the subdominant epitopes now gain, immunologically speaking, a competitive advantage. However, these less exposed domains of spike are less potent inducers of neutralizing antibodies. Now, in case somebody has been vaccinated and that is what we are talking about in case of breakthrough infections, , these subdominant epitopes now gain a competitive advantage and will be able to recall previously primed B memory cells that are producing antibodies which have a lower neutralizing capacity. So the subdominant epitopes that gain a competitive advantage because the strongest neutralizing epitopes have now been hidden by the existing preexisting vaccinational antibodies, are now going to be able to recall in a pre-primed, i.e., a vaccine-primed individual, previously primed antibodies or memory cells that are producing antibodies that have less neutralizing capacity.
That is what I'm calling here the ‘hidden antigenic sin’. Why hidden? Because they are not promoting the stimulation, so to say, of the original vaccinal antibodies, despite reinfection. No, they are eliciting antibodies that were not previously elicited or that were only elicited in very, very low quantities because the antigens that were inducing them were dominated and outcompeted by the stronger neutralizing epitopes. So now we get to a situation where these subdominant epitopes are recalling antibodies with less neutralizing capacity.
And this will lead in fact to a situation where breakthrough infections are causing an increased proportion of poorly neutralizing to even non neutralizing antibodies. And that is the system that will expedite and accelerate immune escape as never seen before.
So, what is the conclusion of this? Well, in fact, the conclusion, if you think about this, is that the emerging omicron variants, by virtue of causing breakthrough infections, are putting themselves under growing immune pressure because they are recalling vaccine-induced antibodies with decreasing neutralizing capacity.
So, you can already imagine that when these Omicron variants circulate and you get these breakthrough infections over and over again, that this will lead to a vicious circle which is going to escalate the rate of immune escape. It already explains, of course, why also updated vaccines, so to say adapted to Omicron, are a complete nonsense. This is an insult to the science. How can you be so stupid? It can only be if you have no clue about this mechanism of immune refocusing. And there are now many, many publications that describe the evolution of how the immune response is getting enriched in poorly neutralizing and non-neutralizing antibodies.
And all of these data are completely compatible with this theory of immune refocusing and hidden antigenic sin.
So, because of that, we are seeing now converging receptor-binding domain mutations, so, mutations in the receptor binding domain that are now even enhancing the infectiousness of the virus. So, you first have poorly neutralizing antibodies that are promoted, so to say, or that are recalled, then they are less and less neutralizing, even non-neutralizing. And at the end, what is going on right now as we speak, is that we see in all these variants converging mutations in the receptor-binding domain that are now even enabling enhanced infectiousness of the virus.
So I cannot believe this, that there are professors, leaders of institutes for molecular biology, genetics, et cetera, et cetera who come up with the type of statements shown in this slide. And when I see their argumentation or their reasoning, what could possibly be the pluses and the minuses, the pros and cons of these Omicron-adapted vaccines, these updated vaccines, I mean, this is a shame.
And I would say to the fact checkers, please wait. If you want to vilify me or ridicule me, that's fine. But just wait for the next few weeks or months to see what is happening because I am going to predict what is happening.
So if that happens, at that moment we will see that immune escape will cause what we call ‘antibody dependent – (because it's depending on those antibodies)- enhancement of severe disease’. And that is going to be a real catastrophe. If you look at the COVID-19 hospitalizations and you compare the unvaccinated versus the vaccinated. So, at some point the hospitalizations for the unvaccinated were in higher numbers than for the vaccinated. I mean, this evaluation has never been fair because I always the unvaccinated, they needed hospitalization because of underlying diseases and those underlying diseases were predisposing them of course to Covid-19 whereas the vaccinated, they needed hospitalization because of the vaccination, because of the side effects but because of the vaccination they were of course also protected against severe disease. So, it was never fair to compare unvaccinated and vaccinated just within hospitalized population. But nevertheless, so what we will see is that, and it is going on already, the numbers of the (hospitalized) unvaccinated will drop and will continue to drop, whereas for the (hospitalized) vaccinated, the number of hospitalizations will strongly increase (and it's already starting to increase), but it will have an exponential course. And of course people say, yeah, that's logical because most of the people are vaccinated. So, there's more people landing in hospitals that have severe disease.
Oh, wait a minute, we can do also the ratios, we can do the ratio of hospitalizations in the unvaccinated versus the vaccinated, right? And if we build that ratio and then we compare how this ratio is changing for example between T2 versus T1, i.e., an earlier time point. Well what we will see is that we will have a very dramatic decrease in this ratio, indicating -again that the rate of hospitalization for severe disease in the vaccinated will dramatically increase; we will be able to follow this evolution very easily. So what does it mean in fact for vaccinees? Well first of all we have already seen that they have enhanced susceptibility to infection and we first see this of course with the elderly, the people who have been vaccinated first, who have gotten all their booster shots: third, the fourth, the fifth, you name it. What we will see thereafter, and this is starting to begin right now, is that we will see enhanced susceptibility to COVID-19 disease, not whatever other disease but COVID-19 disease. Of course first in the elderly and then what will follow is enhanced susceptibility of these vaccinees to severe C-19 disease. And so how this will translate practically speaking is that vaccinees who get infected will get C-19 disease but upon reinfection the very same vaccinees will now get severe disease.
So, this is my desperate call for taking drastic and immediate action. So, what could we do? What could we still do? Well of course I was explaining we need to avoid this immune refocusing because this is just going to throw additional fuel on the fire because this is going to escalate and accelerate the immune escape in a direction that is really very detrimental, that will end up in enhanced virulence of a highly infectious virus. So, we cannot give new booster doses like Omicron-updated booster doses.
Of course, the infection rate can only be reduced via chemoprophylaxis with safe and effective antivirals that on top are broadly accessible and affordable. So, I don't care which antivirals but they need to comply with those criteria.
And we know that there are only very, very few drugs that have these properties that are really safe, can do the job, are effective, broadly accessible and affordable. And I tell you, I think this will need to be done in a prophylactic way. We will need to do it right now in highly vaccinated countries and start providing people massively with antivirals. And the reason I'm saying this is that preventing these vaccine breakthrough infections is almost like generating herd immunity. If we can avoid these vaccine breakthrough infections we can start to build herd immunity.
And please remember: the only way, the only way to control and terminate a pandemic is by generating herd immunity. So then, how long would we need to give these antivirals? Forever? No, we would not do this because that would also have a risk of, for example, inducing (drug) resistance. We would need to do this till we have achieved full herd community.
Of course, for the unvaccinated it's much easier. They have trained their natural immunity. I keep saying the unvaccinated will do better and better, will ultimately become resistant to this virus. And the people who are probably best protected against Sars-Covid-2 and all the upcoming variants are those that are unvaccinated and live in highly vaccinated countries.
These are the only two options that we have to diminish this fulminant transmission rate in the population that we see right now and that could lead to this miraculous target that was in fact the purpose of the mass vaccination campaign, which miserably failed, and which is herd immunity.
So, what about the side effects and all post mortality rates in the vaccinees that we have seen have been going up? It's appalling if you see the rates and the kind of side effects, the kind of increase in excess deaths, etc. I have no words to describe it; really. It's appalling, it is unacceptable, it blows me away.
But nevertheless, whether you believe me or not, I'm always saying: if one puts all these side effects and all this excess death rate together, it is still going to be peanuts compared to the kind of losses that we are going to face when the virus evolves as I'm predicting, and which I'm 200% certain of, that it will evolve in that way.
And what about the updated Omicron adapted vaccine? Well, I told you that in the unvaccinated it will enable immune refocusing and in the vaccinees, it will enhance it, so it will make the situation dramatically worse.
It will escape.
And the winning party is not going to be the technocrats, it's not, let's say, the megalomania of mankind, but it's simply the biology. And these experts, these scientists have forgotten about biology. They are blinded by technologies, whether it's for diagnostics, whether it's for surveillance, whether it's for therapeutic purposes, whether it's for preventive purposes. They have forgotten about the essentials of biology.
And that is also why I'm saying, with regard to the COVID-19 battle, the country or the continent that will win is Africa. Because they will build herd immunity. So, with that, as I was saying, my desperate last video message to call on people who are in charge to still intervene in a way that we can limit the losses and the kind of humanitarian crisis that I think we are now really, really facing very closely.
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